Location and Contact__________________________________________________________________________________________
National University of Singapore (NUS), Building E3A
7floor,
Faculty of Engineering
Lab E3A-7-2, Tel: (+65) 6516 6482 (GMT +8 hours)
Click here for campus map
Laboratory coordinates: 1° 17' N, 103° 46' E
Research
Overview_____________________________________________________________________________________
Keywords:
NanoBioanalytics, Biomicrodevices, Microencapsulation, Microcapsule-PCR,
Biosensors, Layer-by-Layer (LbL).
Biomicrodevices: In an interdisciplinary approach
we combine
microfabrication, surface chemistry and molecular biology to create novel
devices using biomolecules (DNA or proteins) for analytical purpose. The final
aim is the full integration of biological materials into microdevice fabrication
processes, targeting mass production compatibility.
Encapsulation: By using the Layer-by-Layer (LbL)
Technology we are creating core shell materials and smart capsules. The LbL
technology allows nanoengineering of surface properties to tailor and
incorporate different properties into capsules and nano/microparticles.
Emerging applications are in medicine, drug delivery,
medical diagnostics and environmental monitoring.
People______________________________________________________________________________________________
Projects_______________________________________________________________________________________________
Biomolecules in Microfabrication
Microcapsule-PCR
Sensor Array for biomicrodevices
Oligonucleotide synthesis
Smart Capsules as Sensors
RP LbL-Microencapsulation
News_______________________________________________________________________________________________
|
Research Highlights |
Patent on novel Layer-by-Layer
encapsulation technology filed (2007)
Patent on a novel bead based microarray decoding/encoding
technology filed (2006) Breakthrough in Bio-MEMS
fabrication technology published: Our group recently published a paper
on the full integration of biological molecules (DNA and proteins) into the
microfabrication process: Trau D., Jiang J., Sucher
J.N., Preservation of the Biofunctionality of DNA and Protein during
Microfabrication,
Langmuir, 22, 877-881, 2006. For the first time it
was demonstrated that e.g. DNA can be immobilized and protected during
following microfabrication steps.
Patents in drug delivery granted: The patents
EP1190123 and
US6833192, granted in 2002
and 2004, describe the LbL coating of microcrystals
with applications in drug delivery and bioanalytics. It is one of the core
patent of the startup company Capsulution AG.
Capsulution AG was founded by Max-Plank Society Scientist, and is dedicated
to drug delivery and smart microcapsules.
Patents in diagnostics granted: The patent
EP0968412 and US6686208, granted in 2002 and 2004, describe a device and method to carry
out evanescent field excitation based fluorescent immunotests. The technology is
used by the company
pes-diagnosesysteme in their point-of-care diagnostic products.
Patent on new biolabel method granted: German (DE0010042023C2)
and European patents were granted on a new biolabel method developed in
Prof Renneberg's (HKUST) and our
research laboratory. The novel biolabel system is described in our
publication
"Nanoencapsulated Microcrystalline
Particles for Superamplified Biochemical Assays" published in Analytical Chemistry,
74 (21), 5480-5486, 2002. The method generates a high signal amplification
and has potential applications as a substitute for enzyme labels in
diagnostics as well as in field tests. The technology is under commercialization by
biognostic AG. |
Seminars_______________________________________________________________________________________________
Prof Donath's
seminar
Laboratory Facilities_______________________________________________________________________________________________
Pictures from
the new Lab here...
Research Links_________________________________________________________________________________________________________
Lab safety________________________________________________________________________________________________
Go to safety page here...
