• Professor
  • Dept Deputy Head - Research & Enterprises

Research Interest

  • Nanobiophotonics & Nanomedicine
  • Biomaterials
  • Biomedical Microdevices


  1. Upconversion Fluorescent Nano-Structure Material and Uses Thereof, US Patent Application No.: 12/445,904, filed on 17/10/2007, US Grant No.: 8,093,566, issued on 10/01/2012.
  2. Method of Patterning and Product(s) Obtained Therefrom, PCT/SG2007/000116, filed on 24/04/2007
  3. Novel Method for Microbead Patterning and Application Thereof, US provisional patent, 60/795,811, filed on 25/04/2006
  4. A New Microfluidic Device for Multiplexed Bead Based Detection, US provisional patent, 60/800,860, filed on 17/05/2006
  5. Monodisperse Infrared-to-Visible Upconversion Nanoparticle Phoshors, US provisional patent, 60/829,768, filed on 17/10/2006
  6. Novel 3-D Pyramidal Porous-Membrane and its Applications Thereof, US provisional patent (PCT application is being filed), 61/491,395, filed on 31/05/2011

Editorial Board Memberships

  1. Recent Patents on Nanotechnology
  2. Recent Patents on Biomedical Engineering
  3. Recent Patents on Engineering
  4. Recent Patents on Material Science
  5. The Open Drug Delivery Journal
  6. The Open Nanoscience Journal
  7. The Open Chemical Engineering Journal
  8. The Open Biomedical Engineering Journal
  9. The Open Nanomedicine Journal
  10. The Open Colloid Science Journal
  11. International Journal of Biomedical Engineering and Consumer Health Informatics
  12. Central European Journal of Engineering
  13. World Journal of Clinical Oncology
  14. Journal of Nanoscience Letters (Associate Editor)
  15. ISRN Nanotechnology
  16. Nanomed
  17. Journal of Biochips & Tissue Chips
  18. Current Science Perspectives

Book Chapters

  1. Jayakumar MK and Zhang Y, Rare Earth Nanomaterials in Fluorescence Microscopy. In Rare Earth Materials in Nanotechnology. ed. Timothy Tan Thatt Yany, 55-78. Singapore: Pan Stanford Publishing Pte. Ltd, 2012.
  2. Tan TTY, Liu S, Zhang Y, Han MY and Selvan ST, Microemulsion Preparative Methods (Overview). In Comprehensive Nanoscience and Technology, 399-441. Maryland Heights: Elsevier B.V., 2010. 43 pp.
  3. Amalraj AI and Zhang Y, Upconverting Fluorescent Nanoparticles for Biological Applications. In Emerging Nanotechnologies for manufacturing, ed. Waqar Ahmed and M.J. Jackson. Micro and Nano Technologies, vol. 978-0-08-094763-1. New York: Elsevier Science, 2009. 20 pp.
  4. Chatterjee DK and Zhang Y, Lanthanide Doped Upconverting Nanoparticles for Biomedical Applications. In Doped Nanomaterials and Nanodevices, ed. Wei Chen. California: American Scientific Publishers, 2008. 20 pp.
  5. Zhang Y and Wang F, Use of nanoparticles as building blocks for bioapplications. In Molecular Building Blocks for Nanotechnology: From Diamondoids to Nanoscale Materials and Applications, ed. G. A. Mansoori, T. F. George, L. Assoufid and G. P. Zhang, 353-376. Topics in Applied Physics, vol. 109. BERLIN: SPRINGER-VERLAG BERLIN, 2007. 24 pp.

Selected Journal Publications

  1. Kwek K Ranjan S, Zhang Y. Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device. Nature Communications 4, 1625 (2013).
  2. Idris NM, Jayakumar MKG, Zhang J, Ho PC, Mahendran R, Zhang Y. In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nature Medicine 18, 1580-1585 (2012).
  3. Jayakumar MKG, Idris NM & Zhang Y. Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 109, 8483-8488 (2012).
  4. Priyam A, Idris NM & Zhang Y. Gold nanoshell coated NaYF4 nanoparticles for simultaneously enhanced upconversion fluorescence and darkfield imaging. Journal of Materials Chemistry 22, 960-965 (2012).
  5. Lim ME, Lee YL, Zhang Y & Chu JJH. Photodynamic inactivation of viruses using upconversion nanoparticles. Biomaterials 33, 1912-1920 (2012).
  6. Paik P & Zhang Y. Synthesis of hollow and mesoporous polycaprolactone nanocapsules. Nanoscale 3, 2215-2219 (2011).
  7. Guo HC, Idris NM & Zhang Y. LRET-Based Biodetection of DNA Release in Live Cells Using Surface-Modified Upconverting Fluorescent Nanoparticles. Langmuir 27, 2854-2860 (2011).
  8. Dou QQ, & Zhang Y. Tuning of the Structure and Emission Spectra of Upconversion Nanocrystals by Alkali Ion Doping. Langmuir 27, 13236-13241 (2011).
  9. Ang LY, Lim ME, Ong LC & Zhang Y. Applications of upconversion nanoparticles in imaging, detection and therapy. Nanomedicine 6, 1273-1288 (2011).
  10. Ong LC, Gnanasammandhan MK, Nagarajan S & Zhang Y. Upconversion: road to El Dorado of the fluorescence world. Luminescence 25, 290-293 (2010).
  11. Li ZQ & Zhang Y. Facile synthesis of lanthanide nanoparticles with paramagnetic, down- and up-conversion properties. Nanoscale 2, 1240-1243 (2010).
  12. Jiang S & Zhang Y. Upconversion Nanoparticle-Based FRET System for Study of siRNA in Live Cells. Langmuir 26, 6689-6694 (2010).
  13. Jiang S, Gnanasammandhan MK & Zhang Y. Optical imaging-guided cancer therapy with fluorescent nanoparticles. Journal of the Royal Society Interface 7, 3-18 (2010).
  14. Guo HC, Qian HS, Idris NM & Zhang Y. Singlet oxygen-induced apoptosis of cancer cells using upconversion fluorescent nanoparticles as a carrier of photosensitizer. Nanomedicine-Nanotechnology Biology and Medicine 6, 486-495 (2010).
  15. Chatterjee DK, Gnanasammandhan MK & Zhang Y. Small Upconverting Fluorescent Nanoparticles for Biomedical Applications. Small 6, 2781-2795 (2010).
  16. Qian HS, Guo HC, Ho PCL, Mahendran R & Zhang Y. Mesoporous-Silica-Coated Up-Conversion Fluorescent Nanoparticles for Photodynamic Therapy. Small 5, 2285-2290 (2009).
  17. Li ZQ, Zhang Y, Shuter B. & Idris NM. Hybrid Lanthanide Nanoparticles with Paramagnetic Shell Coated on Upconversion Fluorescent Nanocrystals. Langmuir 25, 12015-12018 (2009).
  18. Idris NM et al. Tracking transplanted cells in live animal using upconversion fluorescent nanoparticles. Biomaterials 30, 5104-5113 (2009).
  19. Cheng JT, Zhang Y, Gopalakrishnakone P & Chen NG. Use of the Upside-Down Method to Prepare Porous Polymer Films with Tunable Surface Pore Sizes. Langmuir 25, 51-54 (2009).