• Professor
  • Dept Deputy Head - Research & Enterprises

Research Interest

  • Nanobiophotonics & Nanomedicine
  • Biomaterials
  • Biomedical Microdevices


  1. Upconversion Fluorescent Nano-Structure Material and Uses Thereof, US Patent Application No.: 12/445,904, filed on 17/10/2007, US Grant No.: 8,093,566, issued on 10/01/2012.
  2. Method of Patterning and Product(s) Obtained Therefrom, PCT/SG2007/000116, filed on 24/04/2007
  3. Novel Method for Microbead Patterning and Application Thereof, US provisional patent, 60/795,811, filed on 25/04/2006
  4. A New Microfluidic Device for Multiplexed Bead Based Detection, US provisional patent, 60/800,860, filed on 17/05/2006
  5. Monodisperse Infrared-to-Visible Upconversion Nanoparticle Phoshors, US provisional patent, 60/829,768, filed on 17/10/2006
  6. Novel 3-D Pyramidal Porous-Membrane and its Applications Thereof, US provisional patent (PCT application is being filed), 61/491,395, filed on 31/05/2011

Editorial Board Memberships

  1. Microchimica Acta
  2. Recent Patents on Biomedical Engineering
  3. The Open Nanomedicine Journal
  4. International Journal of Biomedical Engineering and Consumer Health Informatics
  5. Central European Journal of Engineering
  6. Journal of Nanoscience Letters (Associate Editor)
  7. ISRN Nanotechnology
  8. Nanomed
  9. Journal of Biochips & Tissue Chips
  10. Current Science Perspectives

Awards or Honours

  1. Highly Cited Researcher (Clarivate Analytics)
  2. Royal Society of Chemistry Fellowship
  3. NUS Provost Chair Professorship
  4. NML Researcher Award
  5. NUS Young Investigator Award

Book Chapters

  1. Jayakumar MK and Zhang Y, Rare Earth Nanomaterials in Fluorescence Microscopy. In Rare Earth Materials in Nanotechnology. ed. Timothy Tan Thatt Yany, 55-78. Singapore: Pan Stanford Publishing Pte. Ltd, 2012.
  2. Tan TTY, Liu S, Zhang Y, Han MY and Selvan ST, Microemulsion Preparative Methods (Overview). In Comprehensive Nanoscience and Technology, 399-441. Maryland Heights: Elsevier B.V., 2010. 43 pp.
  3. Amalraj AI and Zhang Y, Upconverting Fluorescent Nanoparticles for Biological Applications. In Emerging Nanotechnologies for manufacturing, ed. Waqar Ahmed and M.J. Jackson. Micro and Nano Technologies, vol. 978-0-08-094763-1. New York: Elsevier Science, 2009. 20 pp.
  4. Chatterjee DK and Zhang Y, Lanthanide Doped Upconverting Nanoparticles for Biomedical Applications. In Doped Nanomaterials and Nanodevices, ed. Wei Chen. California: American Scientific Publishers, 2008. 20 pp.
  5. Zhang Y and Wang F, Use of nanoparticles as building blocks for bioapplications. In Molecular Building Blocks for Nanotechnology: From Diamondoids to Nanoscale Materials and Applications, ed. G. A. Mansoori, T. F. George, L. Assoufid and G. P. Zhang, 353-376. Topics in Applied Physics, vol. 109. BERLIN: SPRINGER-VERLAG BERLIN, 2007. 24 pp.

Selected Journal Publications

  1. K. K. Zeming, T. Salafi, S. Shikha, Y. Zhang, Fluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array. Nature Communications 9, (2018).
  2. Z. D. Lei et al., Boosting lithium storage in covalent organic framework via activation of 14-electron redox chemistry. Nature Communications 9, (2018).
  3. A. Bansal, F. Y. Yang, T. Xi, Y. Zhang, J. S. Ho, In vivo wireless photonic photodynamic therapy. Proceedings of the National Academy of Sciences of the United States of America 115, 1469-1474 (2018).
  4. S. Shikha, T. Salafi, J. T. Cheng, Y. Zhang, Versatile design and synthesis of nano-barcodes. Chemical Society Reviews 46, 7054-7093 (2017).
  5. M. K. Gnanasammandhan, N. M. Idris, A. Bansal, K. Huang, Y. Zhang, Near-IR photoactivation using mesoporous silica-coated NaYF4:Yb,Er/Tm upconversion nanoparticles. Nature Protocols 11, 688-713 (2016).
  6. S. S. Lucky, K. C. Soo, Y. Zhang, Nanoparticles in Photodynamic Therapy. Chemical Reviews 115, 1990-2042 (2015).
  7. S. S. Lucky et al., Titania Coated Upconversion Nanoparticles for Near-Infrared Light Triggered Photodynamic Therapy. ACS Nano 9, 191-205 (2015).
  8. N. M. Idris, M. K. G. Jayakumar, A. Bansal, Y. Zhang, Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications. Chemical Society Reviews 44, 1449-1478 (2015).
  9. M. K. G. Jayakumar et al., Near-Infrared-Light-Based NanoPlatform Boosts Endosomal Escape and Controls Gene Knockdown in Vivo. ACS Nano 8, 4848-4858 (2014).
  10. A. Bansal, Y. Zhang, Photocontrolled Nanoparticle Delivery Systems for Biomedical Applications. Accounts of Chemical Research 47, 3052-3060 (2014).
  11. K. K. Zeming, S. Ranjan, Y. Zhang, Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device. Nature Communications 4, 8 (2013).
  12. S. K. Yen et al., Design and Synthesis of Polymer-Functionalized NIR Fluorescent Dyes-Magnetic Nanoparticles for Bioimaging. ACS Nano 7, 6796-6805 (2013).
  13. Y. J. Zhang et al., Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nature Materials 11, 817-826 (2012).
  14. M. K. G. Jayakumar, N. M. Idris, Y. Zhang, Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers. Proceedings of the National Academy of Sciences of the United States of America 109, 8483-8488 (2012).
  15. N. M. Idris et al., In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nature Medicine 18, 1580-U1190 (2012).
  16. N. Bhattarai et al., Natural-Synthetic Polyblend Nanofibers for Biomedical Applications. Advanced Materials 21, 2792-+ (2009).
  17. Z. Q. Li, Y. Zhang, S. Jiang, Multicolor Core/Shell-Structured Upconversion Fluorescent Nanoparticles. Advanced Materials 20, 4765-+ (2008).
  18. Y. Zhang, C. Wang, Micropatterning of proteins on 3D porous polymer films fabricated by using the breath-figure method. Advanced Materials 19, 913-+ (2007).
  19. M. H. Lu, Y. Zhang, Microbead patterning on porous films with ordered arrays of pores. Advanced Materials 18, 3094-+ (2006).
  20. Z. Q. Li, Y. Zhang, Monodisperse silica-coated polyvinylpyrrolidone/NaYF4 nanocrystals with multicolor upconversion fluorescence emission. Angewandte Chemie-International Edition 45, 7732-7735 (2006).
  21. C. Wang, Y. Zhang, Protein micropatterning via self-assembly of nanoparticles. Advanced Materials 17, 150-+ (2005).
  22. W. B. Tan, Y. Zhang, Multifunctional quantum-dot-based magnetic chitosan nanobeads. Advanced Materials 17, 2375-+ (2005).