Michael Raghunath
Associate Professor
MD (Mainz Germany)
Habilitation (PhD, Muenster, Germany)
 
Lab Supervisor, Tissue Modulation Laboratory
Faculty of Engineering
9 Engineering Drive 1
Singapore 117576


Tel: +(65) 6516-7657
Fax: +(65) 6872-3069
 
Dr Raghunath is a physician scientist and holds a joint appointment both at the Division of Bioengineering and Biochemistry (Faculty of Medicine). He has strong academic, clinical (dermatology) and industrial background (see CV).
 
Academic qualifications
1. MD, University of Mainz Medical School, Germany (1987)
2. Doctorate in Medicine, Mainz University, Germany (1988)
 3. Habilitation (= PhD equivalent) and appointment as Lecturer in Physiol. Chemistry & Pathobiochemistry, University of Muenster, Germany (1997)
4. Appointed Unscheduled (=associate) Professor, University of Muenster, Germany (July 03)
5. Associate Professor for Bioengineering & Biochemistry, NUS (since August 2003)
 


Activity/Research
Dr. Raghunath´s Research Thrust spans the field of extracellular matrix biology and pathobiochemistry, and skin biology (wound repair and cornification disorders)
1. Scar Wars
2. Neovascularisation of tissue and vascularisation of biomaterials
3. Biological crosslinking using transglutaminases
4. Modeling the stem cell niche
 


Selected Publications
Dr Raghunath currently holds currently over 50 international publications, more than 70 conference papers, has giveen over 50 invited lectures and has contributed to book chapters and reviews. (complete publication list)

1. Tschank G, Raghunath M, Günzler V, Hanauske-Abel HM. 1987. Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selective suppress cellular hydroxyprolyl biosynthesis. Biochem J, 248:625-633

2. Raghunath M, Bruckner P, Steinmann B. 1994. Delayed triple helix formation of mutant collagen from patients with osteogenesis imperfecta. J Mol Biol, 236:940-949

3. Raghunath M, Kielty CM, Steinmann B. 1995. Truncated profibrillin of a Marfan patient is of similar size as fibrillin, but more N-glycosylated and disturbs microfibril assembly. J Mol Biol, 248: 901-909

4. Raghunath M, Höpfner B , Aeschlimann D, Lüthi U, Meuli M, Altermatt S, Gobet R, Bruckner-Tuderman L, Steinmann B. 1996. Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts: anchoring fibrils are a target for tissue transglutaminase. J Clin Invest 98:1174-1184

5. Kielty CM, Raghunath M, Siracusa L, Sheratt MJ, Shuttleworth CA, Peters R, Jimenez S 1998. The tight skin mouse: demonstration of mutant fibrillin-1 production and microfibrillar abnormalities. J Cell Biol 140:1-8

6. Raghunath M, Tschödrich-Rotter M, Bruckner-Tuderman L, Peters R, Meuli M. 1998. The microfibrillar apparatus of normal and regenerating human skin contains latent transforming growth factor- -binding protein-1 (LTBP-1) and is a major repository for latent TGF- -1. J Invest Dermatol, 111:559-564

7. Raghunath M, Ritty T, Hamstra D, Parks E-S, Tschödrich-Rotter M, Peters R, Rehemtulla A, Milewicz D. 1999. Carboxyterminal conversion of profibrillin to fibrillin at a basic by PACE/furin-like activity required for incorporation in the matrix. J Cell Sci 112:1093-1100

8. Raghunath M, Hennies HC, Ahvazi B, Vogel M, Reis A, Steinert PM, Traupe H. 2003. Self-healing collodion baby: a dynamic phenotype explained by a particular transglutaminase-1 mutation. J Invest Dermatol, 120:224-228.

9. Böhm M, Raghunath M, Sunderkötter C, Schiller M, Ständer S, Brzoska T, Cauvet T, Schiöth HB, Schwarz T, Luger TA. 2004. Collagen metabolism - a novel target of the neuropeptide -melanocyte-stimulating hormone. J Biol Chem, 279: 6959-6966

10.  Raghunath M, Tontsidou L, Oji V, Aufenvenne K, Schurmeyer-Horst F, Jayakumar A, Stander H, Smolle J, Clayman GL, Traupe H. 2004. SPINK5 and Netherton Syndrome: Novel Mutations, Demonstration of Missing LEKTI, and Differential Expression of Transglutaminases. J Invest Dermatol 123:474-483