Research Interests

My main research interest is the development and use of computational models of biological systems at different scales. I have been involved in modelling the function of the heart and the gastrointestinal system in health and disease. Focus areas include (see here for further information)

1. Modelling protein kinetics of ion channels.
2. Biophysical models of the cellular electrical activity that underlies contraction of the heart and the stomach.
3. Cellular coupling and whole organ electrophysiology.
4. Development of efficient C++ code for solving large scale finite elements problems in computational biology (see here)

Selected peer-reviewed journal publications (Click on the ReseearcherID Badge for the full list in chronological order)

1. Corrias, A., Buist, M.L. A quantitative cellular description of gastric slow wave activity. American Journal of Physiology 2008, Apr;294(4):G898-995. Pubmed

2. Cooper J, Corrias A., Gavaghan D, Noble D, Considerations for the use of cellular electrophysiology models within cardiac tissue simulations. Progress in Biophysics and Molecular Biology 2011 107(1):74-80 Pubmed

3. Corrias, A., Giles W, Rodriguez B. Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers. American Journal of Physiology 2011, May;300(5): H1806-13. Pubmed

4. Corrias, A., Pathmanathan, P., Gavaghan, D., Buist M.L. Modelling tissue electrophysiology with multiple cell types: applications of the extended bidomain framework. Integrative Biology 2012. 4(2):192-201. Pubmed

5. Corrias, A., Buist, M.L. A Quantitative Model of Gastric Smooth Muscle Cellular Activation. Annals of Biomedical Engineering 2007, Sep;35(9):1595-607. Pubmed

6. Pueyo, E., Corrias, A., Virag, L., Jost, N., Szel, T., Varro, A., Szentandrassy, N., Nanasi, P.P., Burrage, K. and Rodriguez, B. A Multiscale Investigation of Repolarization Variability and Its Role in Cardiac Arrhythmogenesis. Biophysical Journal 2011, 101(12):2892:2905. Pubmed