SHAO Huilin

  • Assistant Professor

2013 Ph.D in Biophysics, Harvard University, USA

PhD in Medical Engineering and Medical Physics, Harvard-MIT Health Sciences and Technology (HST), USA
2007 BA in Biological Sciences, BA in Physics, Cornell University, USA

Research Interest

  1. Circulating biomarkers (e.g., exosomes, extracellular vesicles) for noninvasive diagnostics and therapeutics
  2. Novel assay development for point-of-care medical applications
  3. Synthesis, characterization and biomedical applications of organic and inorganic nanomaterials
  4. Integration of microfluidic systems for molecular analyses
  5. Development and implementation of highly sensitive miniaturized magnetic, optical and electrical sensors

Selected Awards & Honours

  1. Independent Fellowship, Institute of Molecular and Cell Biology, A*STAR, 2014
  2. Travel Award, IEEE EMBS Micro and Nanotechnology in Medicine, 2012
  3. Graduate Student Award, Center of Cancer Nanotechnology Excellence, MIT, 2011
  4. James Mills Peirce Award, Harvard University, 2008
  5. National Science Scholarship (PhD), A*STAR, 2008
  6. Hartman Prize in Experimental Physics, Cornell University, 2007
  7. Hughes Scholar in Biological Sciences, Cornell University, 2006
  8. National Science Scholarship (BS), A*STAR, 2004

Recent Invited Talks

  1. National Neuroscience Institute (NNI), Singapore, 2016
  2. National Cancer Centre Singapore (NCCS), Singapore, 2015
  3. Institute of Molecular and Cell Biology (IMCB), Singapore, 2014
  4. Massachusetts General Hospital, Center for Systems Biology, Boston, MA, USA, 2013
  5. Harvard Medical School, Microvesicle and Exosome Seminar Series, Boston, MA, USA, 2012
  6. MIT Center of Cancer Nanotechnology Excellence (CCNE) Seminar, Boston, MA, USA, 2012

Selected Journal Publications

  1. Shao H.*, Chung J.*, Lee K., Balaj L., Min C., Carter B. S., Hochberg F. H., Breakefield X. O., Lee H., Weissleder R. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nature Communications 6, 6999 (2015).
  2. Im H.*, Shao H.*, Park Y., Peterson V. M., Castro C. M., Weissleder R., Lee H. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nature Biotechnology 32, 490-495 (2014).
  3. Shao H., Chung J., Balaj L., Charest A., Bigner D. D., Carter B. S., Hochberg F. H., Breakefield X. O., Weissleder R., Lee H. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature Medicine 18, 1835-1840 (2012).
  4. Shao H., Chung J., Issadore D. Diagnostic technologies for circulating tumor cells and exosomes. Bioscience Reports 36, e00292 (2016).
  5. Im H.*, Castro C. M.*, Shao H., Liong M., Song J., Pathania D., Fexon L., Min C., Avila-Wallace M., Zurkiya O., Rho J., Magaoay B., Tambouret R. H., Pivovarov M., Weissleder R., Lee H. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci USA. 122, 5613-5618 (2015).
  6. Lee K., Shao H., Weissleder R., Lee H. Acoustic purification of extracellular microvesicles. ACS Nano 9, 2321-2327 (2015).
  7. Chung J.*, Shao H.*, Reiner T., Issadore D., Weissleder R., Lee H. Cell sorting: microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells. Advanced Healthcare Materials 1432-436 (2012). Cover.
  8. Issadore D., Chung J.*, Shao H.*, Liong M., Ghazani A. A., Castro C. M., Weissleder R., Lee H. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Science Translational Medicine 4141ra92 (2012). Cover.
  9. Shao H., Min C., Issadore D., Liong M., Yoon T. J., Weissleder R., Lee H. Magnetic nanoparticles and microNMR for diagnostic applications. Theranostics 2, 55-65 (2012).
  10. Shao H., Yoon T. J., Liong M., Weissleder R., Lee H. Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein Journal of Nanotechnology 1, 142-154 (2010).