Name

 

Toh Yi-Chin

 

Qualification

 

2002-2008    Ph.D, NUS Graduate School of Integrative Sciences and Engineering, NUS

1997-2001    B.Eng (Hon), Chemical Engineering, NUS


 

Appointment Status

 

Assistant Professor

 

Department

 

Department of Biomedical Engineering

 

Contact

 

.Email: biety@nus.edu.sg

Tel Office: +(65) 65161486

Fax:            +(65) 6872 3069

 

Lab website: Micro-Tissue Engineering Lab (µTE lab)

 

Research Interests

Experimental Mechanics, Biomechanics, Functional Tissue Engineering

Research Projects


1. Application of microfluidics and bio-MEMs to impose spatio-temporal control over human embryonic stem cell fate specification during normal and pathogenic embryonic tissue patterning

2. Organs-on-a-chip for drug testing applications

 

 

Teaching

1. BN4301 Principles of Tissue Engineering

 

 
 

Awards and Honours

 

National University of Singapore Research Scholarship
A*STAR Graduate Scholarship
A*STAR International Fellowship.

 

Selected Publications


1
1. C.G. Anene-Nzelu, K.Y. Peh, A. Fraiszudeen, Y.H. Han, S. H. Ng, H. Yu, Y.C. Toh, H.L. Leo, A scalable method for aligning 3D micro-tissues in microfluidic chips, 2013, Lab on a Chip, 13 (20), 4124 - 4133
2
2. C.G. Anene-Nzelu, D. Choudhury, H. Li, A. Fraiszudeen, K.Y. Peh, Y.C. Toh, S. H. Ng, H. L. Leo, H. Yu, Scalable cell alignment on optical media substrates, 2013, Biomaterials, 34(21): 5078-5087
3
3. Y. Wang, Y.C. Toh, Q.S. Li, B.X. Zheng, B. Nugraha, T.B. Lu, Y. Gao, H. Yu, Mechanical compaction directly modulates the dynamics of bile canaliculi formation, 2013, Integrative Biology, 5 (2): 390 - 401
 Featured in Global Medical Discovery (ISSN 1929-8536), Jan 2013
4
4. Y.C. Toh, K Blagovic, H. Yu, J. Voldman, Spatially organized in vitro models instruct asymmetric stem cell differentiation, 2011, Integrative Biology, 3: 1179-1187
5
5. Y.C Toh, J. Voldman, Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, FASEB Journal, 2011, 25: 1208-1217
6
. Y.C. Toh, K. Blagovic, J. Voldman, Advancing Stem Cell Research with microtechnologies: opportunities and challenges, Integrative Biology, 2010, 2: 305-325
7
Y.C. Toh, T. C. Lim, D. Tai, G. Xiao, D. van Noort and H. Yu, A microfluidic 3D hepatocyte chip for drug toxicity testing, Lab on a Chip, 2009, 9 (14): 2026-2035
8
C. Zhang, S. M. Chia, S. M. Ong, S. Zhang, Y. C. Toh, D. van Noort and H. Yu, The controlled presentation of TGF-b1 to hepatocytes in a 3D microfludic cell culture system, Biomaterials, 2009, 30: 3847-3853
9
S. M. Ong, C. Zhang, Y. C. Toh, S. H. Kim, H. L. Foo, C. H. Tan, D. van Noort, S. Park, H. Yu, A gel-free 3D microfluidic cell culture system, Biomaterials, 2008, 29(22): 3237-3244
10
L. Kim, Y.C. Toh, J. Voldman, H. Yu. A Practical Guide to Microfluidic Perfusion Culture of Adherent Mammalian Cells. Lab on a Chip, 2007, 7: 681-694.
11
Y.C. Toh, C. Zhang, J. Zhang, Y.M. Khong, S. Chang, V.D. Samper, D. van Noort, D.W. Hutmacher and H.Yu. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab on a Chip, 2007, 7: 302-309. Featured in RSC's Chemical Biology, 2007, Issue 4