Name

 

Ronen Zaidel Bar

 

Qualification

 

Ph.D.


 

Appointment Status

 

Assistant Professor

 

Department

 

Department of Biomedical Engineering
Mechanobiology Institute


 

Contact

 

National University of Singapore
Mechanobiology Institute,
T-lab building #05-01, 5A Engineering Drive 1,
Singapore 117411

Email:biezbr@nus.edu.sg

Tel: +65 6601 1451
Fax: +65 6872 6123


Website: www.CellAdhesionLab.com


 

Research Interests


We study the regulation of cell-cell adhesion during morphogenesis and cell migration. We use microscopy in cell cultures and in the model organism C. elegans to address basic questions about how cells connect to and sense their environment, be it a neighboring cell or the surrounding matrix. We are particularly interested in the role forces play in the regulation of cell adhesion and in the interplay between cell adhesion and the actin and microtubule cytoskeletons.

 

 

Teaching

 

BN502

 

Awards and Honours


NRF fellowship 2010

 

Membership in Scientific/Professional Organization


ASCB member F1000 contributor

 

Selected Publications

 

Zaidel-Bar R., Joyce MJ., Lynch AM., Witte K, Audhya A, Hardin JD. (2010) The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J Cell Biol 191(4):761-769. ZaidelBar2010c <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2010c.pdf>

 

Zaidel-Bar R., Geiger B. (2010) The switchable integrin adhesome. J Cell Sci 123(9):1385-8. ZaidelBar2010b <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2010b.pdf>

 

Zaidel-Bar R., Miller S., Broday L. (2010) Molting-specific downregulation of C. elegans body-wall muscle attachment sites: The role of RNF-5 E3 ligase.. Biochem Biophys Res Commun. ZaidelBar2010 <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2010.pdf>

 

Zaidel-Bar R. (2009) Evolution of Complexity in the Integrin Adhesome. J Cell Biol 186(3):317-21

Zaidel-Bar, R., Itzkovitz, S. and Geiger, B. (2009). Protein networks in integrin-mediated adhesions. In Systems Biomedicine: Concepts and Perspectives (ed. E.T. Liu and D.A. Lauffenburger), pp 139-152. Oxford: Academic Press. ZaidelBar2009b <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2009b.pdf>

 

Raz-Ben Aroush D., Zaidel-Bar R., Bershadsky AD., Wagner HD. (2008) Temporal evolution of cell focal adhesions: experimental observations and shear stress profiles. Soft Matter 4(12): 2410-2417. Dikla2008 <http://celladhesionlab.com/wp-content/uploads/2010/05/Dikla2008.pdf>

 

Lockwood C., Zaidel-Bar R., Hardin JD. (2008) The C. elegans Zonula Occludens ortholog ZOO-1 cooperates with the cadherin-catenin complex to recruit actin during epidermal morphogenesis Curr Biol 18(17):1333-7. Lockwood2008 <http://celladhesionlab.com/wp-content/uploads/2010/05/Lockwood2008.pdf>

 

Zaidel-Bar, R., Itzkovitz S., Ma™ayan A., Iyengar R., Geiger B. (2007) Functional atlas of the integrin adhesome. Nat Cell Biol 9(8):858-67. ZaidelBar2007b <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2007b.pdf>

 

Zaidel-Bar R., Milo R., Kam Z., Geiger, B. (2007) A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci 120(Pt1):137-48. ZaidelBar2007 <http://celladhesionlab.com/wp content/uploads/2010/05/ZaidelBar2007.pdf>

 

Zaidel-Bar R., Kam Z., Geiger B. (2005). Polarized down-regulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow . J Cell Sci 118(Pt17):3997-4007. ZaidelBar2005 <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2005.pdf>

 

Zaidel-Bar R., Cohen M., Addadi L., Geiger B. (2004). Hierarchical assembly of cell-matrix adhesion complexes. Biochem. Soc. Trans., 32(3). ZaidelBar2004 <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2004.pdf>

 

Zaidel-Bar R., C. Ballestrem, Z. Kam, B. Geiger (2003). Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.  J Cell Sci 116(Pt22):4605-13. ZaidelBar2003 <http://celladhesionlab.com/wp-content/uploads/2010/05/ZaidelBar2003.pdf>