Biofluid Mechanics
Research Laboratory
• Computational and experimental biofluid mechanics
• Heart valve engineering
• Artificial liver device
• In vitro drug screening platform
Areas of Research
Educational Backgrounds
• PhD. (Bioengineering) Georgia Institute of Technology, 2005
• M.S. (Mechanical Engineering) Georgia Institute of Technology, 2001
• M.Eng. (Mechanical Engineering) Nanyang Technological University, 2000
• B.Eng. (Mechanical Engineering) Leeds University, 1996
Selected Publications
Leo Hwa Liang
Assistant Professor
Division of Bioengineering
Office: E2-02-20
Lab: E3-05-18
Phone: +65-6516-5608
Fax: +65-6872-3069
Email: bielhl@nus.edu.sg
Post-graduate positions for Jan 2010 intake:
If you are interested in working with us, please email me at bielhl@nus.edu.sg
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1.L. Xia, S. Ng, R. B. Han, X. Y. Tuo, G. F. Xiao, H. L. Leo*, T. M. Cheng*, H. Yu, “Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing, “ Biomaterials, accepted for publication July 2009.
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2.D. H. Frakes, K. Pekkan, L. P. Dasi, H. D. Kitajima, D. de Zelicourt, H. L. Leo, J. Carberry, K. Sundareswaran, H. Simon, A. P. Yoganathan*, “Modified Control Grid Interpolation for the Reconstruction of Fluid Flows.” Expt. in Fluid, accepted for eprint, 11 May 2008
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3.S. F. Zhang, X. Lei, S. M. Ong, Y. C. Toh, H. L. Leo*, D. Van Noort and Hanry Yu*, “Microfabricated silicon nitride membranes for hepatocyte sandwich culture”, Biomaterials, 2008 Oct;29 (29):3993-4002.
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4.Yanan Du, R. B. Han, F. Wen, Susanne S. S. Ng, H. L. Leo*, T Wohland and Hanry Yu*, “3D Hepatocyte Monolayer’ Culture in a Novel ‘Synthetic Sandwich Configuration”, Biomaterials, 2008 (29): 290-301.
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5.H. L. Leo, H. A. Simon, L. P. Dasi, A. P. Yoganathan*, “Effect of Hinge Gap Width on the Micro-Flow Structures in 27 mm Bileaflet Mechanical Heart Valves,” J of Heart Valve Diseases, 2006 Nov 15 (6): 800-808.
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6.H. L. Leo, L. P. Dasi, J. Carberry, A. P. Yoganathan*, “Hemodynamic Assessment of Three Polymeric Heart Valves using Three-Dimensional Particle Image Velocimetry,” Annal of Biomedical Engineering, 2006 Jun, 34 (6): 936-952.
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7.L. Ge, H. L. Leo, F. Sotiropoulos and A. P. Yoganathan*, “Flow in a Mechanical Bileaflet Heart Valve at Laminar and Near-Peak Systole Flow Rates: CFD Simulations And Experiments,” J Biomech Engineering, 2005 Oct; 127(5): 782-97.
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8.H. L. Leo*, H. Simon, J. Carberry, S. C. Lee and A. P. Yoganathan*, “A Comparison of Flow Field Structures of Two Tri-Leaflet Polymeric Heart Valves,” Annals of Biomedical Engineering, 2005 (33): 429-443.
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9.H. L. Leo, Z. He, J. T. Ellis and A. P. Yoganathan*, “Microflow Fields in the Hinge Region of the CarboMedics Bileaflet Mechanical Heart Valve Design,” Journal of J Thoracic and Cardiovascular Surgery, 2003 (124): 561-574.
*corresponding authors