CHWEE TECK LIM PhD
Professor
Division of
Bioengineering & Department of Mechanical Engineering
National University
of Singapore, 9 Engineering Drive 1.
Tel: (65) 6516 7801
Fax: (65) 6779 1459 Email: ctlim@nus.edu.sg
EDUCATION
BEng (First Class Honours), National
PhD,
SchOLARSHIPS,
AWARDS & HONORS
First Prize, International Scanning Probe
Microscopy Image Contest 2009
Best Oral Presentation, International
Conference on Materials for Advanced Technologies 2009
Tan Kah Kee Inventor’s Award (Merit) 2009
Most Cited Author 2005-2008, Acta Biomaterialia
Best Poster Award, NUS GPBE-Tohoku University conference 2008
Young Investigator Award (First Prize),
International Conference on Biomedical Engineering, Singapore, 2008
Cover Story-R&D at the nano scale, Pharma
Focus Asia Magazine, Iss 7, 2008
Best Poster Award, 3rd MRS-S Conference on Advanced Materials, Singapore, 2008
Best Poster Award, Office of Life Science Conference, Singapore, 2007
Research cited by MIT
Technology Review as one of the top ten emerging technologies of 2006
Meeting Graduate Student Award (Gold), MRS Fall Meeting,
Outstanding Paper Award, MRS Fall Meeting,
MRS-S National Conference, Best Poster Award, 2004
Excellent Paper Award, 2nd World Congress of Chinese Biomedical Engineers,
Faculty Teaching Commendation Award, 2003-2006
Faculty Teaching Excellence Award, 2002
Cambridge Commonwealth Trust Scholarship, Overseas Student Research
Award, Cambridge University Board of Graduate Studies Lundgren Award, Ford of
British Fund Scholarship, Tan Kah Kee Foundation Postgraduate Scholarship,
1992-1996
SOME
MAJOR APPOINTMENTS
Deputy Director,
NUS Life Sciences Institute (2006 - 2009)
Fellow,
Faculty Associate,
Assistant Dean,
Faculty of Engineering,
Programme Manager & Founding Member,
Division of Bioengineering,
Coordinator & Founding Member,
Lab Head, Nano Biomechanics Lab, Division of
Bioengineering (2001 - present)
Ministry of Education Life Sciences Guidebook
Committee (2001)
Ministry of Education
National Science Curriculum Review Committee (1998 - 1999)
VISITING
PROFESSORSHIPs & PROGRAMMES
JSPS visiting
programme – Nagoya Institute of Technology, Osaka University, Tohoku University
(2006)
Kyoto University,
Nagoya Institute of Technology, Osaka University, Tohoku University, Japan
(2005)
21st
Century
Dept of Materials
Science & Engineering, MIT (2003)
Cavendish Laboratory,
Dept of Engineering,
EDITORIAL
BOARDS
Editorial Board Member, Medical and
Biological Engineering and Computing
Editorial Board Member, Journal of
Biorheology
Editorial Board Member, Journal of the Royal
Society - Interface
Associate Editor, Cellular &
Molecular Bioengineering
Editorial Board Member, COSMOS
Associate Editor, Molecular and Cellular Biomechanics
Member of the Editorial Board, Mechanics & Chemistry of Biosystems
(2005)
Associate Editor,
International Journal of Nanoscience
PROFESSIONAL
SOCIETY/COMMITTEE
Professional Fellow,
The Institute of Nanotechnology, UK
Member, World
Association for Chinese Biomedical Engineers
Member, Institute of
Engineers, Singapore
Member, Biomedical
Engineering Society, Singapore
MAJOR
RESEARCH INTERESTS
Cell & molecule biomechanics,
Mechanotransduction/Mechanobiology, Nanobiomaterials
Overseas research collaborators: Columbia University, Duke University, MIT, Paris-Diderot University,
Caltech, UIUC, Institut Pasteur, Vanderbilt University, Tubingen University, Tohoku University,
Peking University, University of Hong Kong.
Selected
PLENARY/KEYNOTE/INVITED LECTURES
2009
1.
Tan S.J, Tan M.H., Lim C.T. At the
Circulating Tumor Cells (CTCs): Emerging Technologies for Detection, Diagnosis
and Treatment Meeting, NIH, USA, 2009.
2.
Lim C.T., At the World Congress on
Medical Physics & Biomedical Engineering, Munich, Germany, 2009.
3.
Lim C.T., At the Technical Seminar Series, Institute
of Microelectronics, A*STAR, Singapore, 2009.
4.
Li A., Tan K.S.W., Lim C.T., At the 36th
International Congress of Physiological Sciences, Japan, 2009.
5.
Li A., Tan K.S.W., Lim C.T., At the 10th US National
Congress on Computational Mechanics, USA, 2009.
6.
Vedula S.R.K., Lim T.S., Hunziker W., Lim C.T., At
the 5th International Conference on Materials for Advanced Technologies (ICMAT
2009), Singapore, 2009.
7.
Lim C.T., At the CEE Mechanics Seminar Series, MIT,
USA, 2009.
8.
Lim C.T., At the GEM4 Summer School on Cellular and
Molecular Mechanics with a focus on Enabling Technologies, UIUC, USA, 2009.
9.
Lim
C.T., Li A., K.S.W. Tan, At the International Conference on Computational and
Experimental Engineering Sciences, Phuket, Thailand, 2009.
2008
1.
Lim C.T., At the Nano Biomechanics Workshop, 2008.
2.
Li A., Tan K.S.W., Lim C.T. At the 2nd Mechanobiology Workshop,
Singapore, 2008.
3.
Lim C.T. At the Society of Engineering Science 45th Annual
Technical Meeting, Urbana-Champaign, USA, 2008.
4.
Lim C.T. At the Department of Microbiology,
University of Illinois at Chicago, Chicago, USA, 2008.
5.
Li A., Tan K.S.W., Lim C.T. At the Materials Science and Technology Annual
Meeting, Pittsburgh, USA, 2008.
6. Lim C.T. At the MICCAI Conference 2008, New York,
USA, 2008.
7. Lim C.T. At the Department of Advanced Materials and
Nanotechnology, College of Engineering, Peking University, Beijing, China,
2008.
8. Lim C.T. At the National Center for Nanoscience and
Technology, Beijing, China, 2008.
9. Lim C.T. At the IUMRC-International Conference on
Electronics Materials, Sydney, Australia, 2008.
10. Lim C.T. At the GEM4 Summer School with a focus on
Cardiovascular Diseases, Caltech, USA, 2008.
11. Lim C.T. At Biomedical Engineering Seminar, Faculty
of Medicine, University of Hong Kong, China, 2008.
12. Lim C.T. At the Global Center of Excellence Seminar,
Tohoku University, Japan, 2008.
13. Lim C.T. At the Global Center of Excellence Seminar,
Shinshu University, Japan, 2008.
14. Lim C.T. At the IUTAM Symposium on Modeling
Nanoscale Materials & Nanosystems, Denmark, 2008.
15. Lim C.T. At the Bioengineering Interest Group (BIG)
Seminar, University of Illinois at Urbana-Champaign, USA, 2008.
16. Lim C.T. At the 2nd Singapore Scanning Probe
Microscopy Symposium (SingSPM), Singapore, 2008.
17. Lim C.T. At the CCO interdisciplinary workshop on Biological Interfaces:
Measurement and Applications, Singapore, 2008.
18. Lim C.T. At the Singapore Immunological Network,
A*STAR, Singapore, 2008.
19. Lim C.T. At 5th International Symposium of
2007 Tohoku University Global COE Program, Japan, 2008.
20. Lim C.T. At the MRS Spring Meeting, San Francisco,
USA, 2008.
21. Lim C.T. At the 13th Meeting on
Thrombosis and Rheology, Tokyo, Japan, 2008.
22. Lee GYY and Lim CT, At the International Conference on Multiscale Modeling and Simulation, India, 2008.
2007
1. Vedula SRK, Lim TS, Hunziker W, Lim CT, At the 3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering, Singapore, 2007.
2. Lee GYY and Lim CT, At the 3rd
Asian-Pacific Congress on Computational Mechanics 2007, Kyoto, Japan, 2007.
3. Lim CT, At the Gordon Laboratory Seminar Series,
Dept of Materials Science & Metallurgy, University of Cambridge, UK, 2007.
4. Lee GYY and
5.
6. Lee GYY and Lim CT, At 9th U.S. National
Congress on Computational
7. Lim CT, At 3rd WACBE World Congress on
Bioengineering, Thailand, 2007.
8. Lim CT, At International Conference on Materials for
Advanced Technologies, Singapore, 2007.
9.
10. Lim CT, At SingSPM Symposium, Singapore, 2007.
11.
12.
13.
14. Lim CT, At Workshop on the Mechanical Behavior of
Systems at Small Length Scales-2, Indian Institute of Sciences, Bangalore,
India, 2007.
15. Lim CT, At Workshop on
Moving Interface Problems and Applications in Biological Flows, Singapore, 2007.
2006
1.
2. Lim CT and Tan KSW, At 5th East Asian
Biophysics Symposium & 44th Annual Meeting of the Biophysical Society
of Japan, Okinawa, Japan, 2006.
3.
4.
5. Lim CT. At 21st
Century Center of Excellence Programme Seminar, Tohoku University, Japan, 2006.
6. Lim CT. At Workshop on Biomedical
Engineering, University of Hong Kong, China, 2006.
7. Lim CT. At Biological Materials Symposium,
8. Lim CT. At 1st International Workshop on
Lab-on-Chip: Modeling, Fabrication and Application, Singapore, 2006.
9. Mills JP, M Diez, Lim CT, Tan KSW, G Milon and S Suresh. At Symposium on
Physics and Mechanics of Advanced Materials, Singapore, 2006.
10. Ng SY, Tan EPS, Sow CH and Lim CT. At
2nd MRS-S Conference on Advanced Materials, Singapore, 2006.
2005
1.
Lim CT. At Pacifichem, Hawaii, USA, 2005.
2. Lim
CT. At
3. Lim
CT. At National
4.
5.
6.
7.
8.
9.
Lim CT. Li A, Tan KSW. At Institut Pasteur, Paris,
France, 2005.
10.
11.
12. Lim CT. Invited lecture, 17th Bioengineering Conference,
Annual Meeting of Bioengrg Div/JSME,
13. Lim CT. Invited lecture, International
Nanotechnology Workshop, Indian Institute of Technology (
2004
1.
2. Lim CT. Invited lecture, Asia Nano Forum Special Workshop on Nanotechnology, NANOMAT
3.
4. Lim CT. Invited lecture, MRS-S National Conference
on Advanced Materials,
5. Lim CT. Invited lecture, International Workshop on Nanomechanics,
6. Lim CT. Invited lecture, 1st
Nanoengineering & Nanoscience Congress,
7. Lim CT, Lee YS, Dao M & Suresh S. Invited
lecture, 43rd Annual Conference for Medical and Biological
Engineering,
2003
1. Suresh S, Lim CT & Dao M. Keynote lecture,
2. Lim CT. Invited lecture, Conference on
Nanobiotechnology,
3. Lim CT. Invited lecture, Nanotechnology Seminar on
Nanoelectronics,
4. Lim CT. Suresh, S & M Dao, Invited lecture. ASME
International Congress on Mechanical
5. Suresh S,
6.
7. Lim CT. At Cavendish Laboratory,
2002
1. Lim CT. Invited lecture, 2nd French-Singapore Biomedical
Engineering Symposium - Biomaterials, Musculoskeletal Biomechanics &
Biomedical Imaging. June 2002.
ENTREPRENEURSHIP
Co-founder
& Director - Robust Dynamics Pte Ltd (a university spinoff company)
Founder
& Director – Clearbridge Biomedics Pte Ltd
PUBLICATIONS
& RESEARCH OUTPUT
More than
330 scientific publications in international journals and conferences, over 120 plenary/keynote/invited lectures, 14 invited/review/leading articles and book and
encyclopedia chapters, editorial works on conference proceedings, international journals
& book, 8 patents & patent applications, 2 university licensing
agreements, 2 technology disclosures & founded 2 companies.
Editorial
Works, Book & Encyclopedia Chapters
1.
Li, A, B Ho, J L Din and C T Lim, Antimicrobial Peptides:
Methods and Protocols, Methods in Molecular Biology, Humana Press, USA, 2008. (in press)
2.
Zhang YS, Tan EPS, Sow CH and Lim CT, Nanomechanical characterization of one-dimensional nanostructures,
Micro and Nano Mechanical Testing of Materials and
Devices, Yang and Li (eds.),Springer, 2009. (in press)
3.
GYH
Lee and CT Lim, Nanotechnology & Human Diseases, Selected Topics in
Nanoscience & Nanotechnology, ATS Wee (ed), World Scientific, 2009.
4.
Zhu Y, Tan EPS, Sow CH and Lim CT, Synthesis of
nanowires, Nanocomposite Coatings and Nanocomposite Materials, Trans Tech
Publications Ltd, Ochsner, Ahmed, Ali (eds), pp. 271-296, 2009.
5.
Vedula SRK, Lim TS, Hunziker
W and Lim CT, Mechanistic Insights into the Physiological Functions of Cell Adhesion
Proteins Using Single Molecule Force Spectroscopy, Molecular & Cellular
Biomechanics, Tech Science Press, USA, pp. 169-183, 2008.
6.
Tan EPS and Lim CT, Structure and Mechanical Properties of Electrospun Nanofibers and
Nanocomposites, Nanotechnology and Tissue Engineering: The Scaffold, CRC Press,
USA, 2008.
7.
Cooke BM and Lim CT,
Mechanical and Adhesive Properties of Healthy and Diseased Red Blood Cells,
Handbook of Hemorheology and Hemodynamics, IOS Press, 2007.
8.
Myers M, Hodge A, Lim CT,
LeSar R eds, Acta Biomaterialia, Special Issue, Elsevier, 2007.
9.
Vedula SRK, Lim TS,
Rajagopal G,
Hunziker W, Lane B, Sokabe M, Lim CT, Role of
External Mechanical Forces in Cell Signal Transduction, Biomechanics at micro-
and nanoscale levels, World Scientific, Singapore, 2007.
10.
Tan EPS, Zhang YZ, Ramakrishna S and Lim CT, Polymer nanofibers: Fabrication,
applications and characterization, Specialty Polymers, IK International, New Delhi,
India, 2007.
11.
Tan EPS and Lim CT, Mechanical Characterization of Nanoscale
Biomaterials, Encyclopedia of Nanoscience & Nanotechnology,
Taylor and Francis Book, New York, USA, 2006.
12.
Tan EPS and Lim CT, Nanomechanical
Characterization of Nanofibers: Experimental Techniques,
Nanomechanics of Materials and Structures, Chuang, Andersen, Wu and Hsieh (eds.), Springer +
Business Media, B.V., USA, pp. 121-138, 2006.
13.
Wee
14.
Lim CT (contributor), Optical Tweezers,
Exploring Nanotechnology Multimedia Encyclopedia, Nanopolis series, iMediasoft,
2005.
15.
Shim VPW, Tanimura S
and Lim CT, eds, International Journal of Impact Engineering,
Special Issue, 24, no. 6-7, United Kingdom, July 2000.
16.
Shim VPW, Tanimura S
and Lim CT, eds, Impact response of materials &
structures. Singapore: Oxford University Press, 1999. 605 pp.
Invited/Review/Leading Articles
1. Fu HX, Chen H, Yan J,
Lim CT, Salt Solution Effects on Overstretching Transitions of
2.
Varghese
B, Zhang YS, Feng YP, Lim CT, Sow CH, Probing the size-structure-property
correlation of individual nanowires, Physical Review B, 2009. (in press)
3.
Vedula
SRK, Mendoz E, Sun W, Lim TS, Li A, Li QS, Lim CT, Human cell as a structure
and machine – An engineering perspective, IES Journal Part A: Civil and
Structural Engineering, 2009 . (in press)
4.
Dai
L, Tan VBC, Sow CH, Lim CT, Atomistic Simulations of Inorganic Nanowires,
Journal of Nanoscience & Nanotechnology, 2008.
5. Zhang YZ, Su B, Venugopal J, Ramakrishna S, Lim CT,
Biomimetic and Bioactive Nanofibrous Scaffolds from Electrospun Composite
Nanofibers, International Journal of Nanomedicine, 2, 623-638, 2007.
6. Zhang YZ, Lim CT, The development of biocomposite nanofibers for tissue
scaffolding applications, JOM, 60, 6, 45-48, 2008.
7.
Lee, GYH, Lim CT, Nanotechnology and human diseases,
COSMOS, 3, 1, 89-101, 2007.
8. Lee GYH,
9.
10. Lim CT, Zhou EH, Li A, Vedula SRK, Fu HX, Experimental
techniques for single cell and single molecule biomechanics, Materials Science
and Engineering C: Biomimetic and Supramolecular Systems, 26, 8, 1278-1288,
2006.
11. Hairul Nizam BR, Lim CT,
Nanoindentation of teeth - A review, Journal of Experimental Mechanics, 21, 1,
35-50, 2006.
12. Tan EPS,
13. Lim CT, Zhou EH, Quek
ST, Mechanical models for living cells - A review, Journal of Biomechanics, 39, 2, 195-216, 2006.
14. Vedula SRK, Lim TS, Kausalya PJ,
Hunziker W, Rajagopal G, Lim CT, Biophysical approaches for studying the
integrity and function of tight junctions, Molecular & Cellular
Biomechanics, 2, 3, 105-124, 2005.
15. Zhang YZ,
16.
Suresh
S, Spatz J, Mills JP, Micoulet A, Dao M, Lim CT, Beil M, Seufferlein T, Connections between disease states and
single-cell mechanical response: human pancreatic cancer and malaria, Acta
Biomaterialia, 1, 15-30, 2005.
17. Chong EJ, Lim CT, Lim
IJ and Phan TT, Application of Biotechnology, Nanotechnology and Tissue
Engineering in Cosmetic Medicine, Kosmetische Medizin, 5/6, 212-216, 2005.
Selected
Peer Review Articles
1.
Chan
KHK, Wong SY, Li X, Zhang YZ, Lim PC, Lim CT, Kotaki M, He CB, Effect of Molecular
Orientation on Mechanical Property of Single Electrospun Fiber of
Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate], Journal of Physical
Chemistry B, 2009. (in press)
2.
DMK
Aladin, KMC Cheung, AHW Ngan, CT Lim, KDK Luk, WW Lu,Nano-structure of Collagen
Fibrils in Human Nucleus Pulposus and its Correlation with Macro-scale Tissue
Mechanics, Journal of Orthopedics Research, 2009. (in press)
3.
YW
Zhu, YS Zhang, L Dai, FC Cheong, VBC Tan, CH Sow , CT Lim, Mechanical
Characterization of Hotplate Synthesized Vanadium Oxide Nanobelts. Acta Materialia, 2009. (in
press)
4.
Chen
Z , Wei B, Mo X, Lim CT, Ramakrishna S, Cui F, Mechanical properties of
electrospun collagen-chitosan complex single fibers and membrane. Materials
Science & Engineering C, 2009. (in
press)
5. Vedula SRK, Lim TS, Hunziker W and Lim CT, Mechanical Insights into the Physiological
Functions of Intercellular Adhesion Molecules at Tight Junctions, Computational and
Theoretical Nanoscience, 2009. (in press)
6.
Fu
HX, Chen H, Yan J, Lim CT, Salt Solution Effects on Overstretching Transitions
of
7.
Meyers,
MA, Lim CT, Li A, Hairul Nizam BR, Tan EPS, Seki Y, McKittrick J, The role of
organic intertile layer in abalone nacre, Materials Science and Engineering C,
C29, 2398-2410, 2009.
8.
Chen
ZG, Wei B, Mo XM, Lim CT, Ramakrishna S, Cui FZ, Mechanical properties of
electrospun collagen–chitosan complex single fibers and membrane, Materials Science
& Engineering C, C 29, 2428–2435, 2009.
9.
Yang
C, Wang X, Li HZ, Lim CT, Li J, Cationic Polyrotaxanes as Gene Carriers:
Physicochemical Properties and Real-time Observation of DNA Complexation, and
Gene Transfection in Cancer Cells, Journal of Physical Chemistry B, 113, 22,
7903-7911, 2009.
10. Vedula, S R K, T S Lim, P J Kausalya, B Lane, G Rajagopal, W. Hunziker, C
T Lim, Quantifying
forces mediated by integral tight junction proteins in cell-cell adhesion,
Experimental Mechanics, 49, 1, 3-9, 2009.
11. Dai L, Sow CH, Lim
CT, Cheong WCD, Tan VBC, Numerical Investigations into the Tensile Behavior of
TiO2 Nanowires: Structural Deformation, Mechanical Properties and Size Effects,
Nano Letters, 9, 2, 576-582, 2009.
12.
Tan
SJ, Yobas L, Lee GYH, Ong CN, Lim CT, Microdevice for the isolation and
enumeration of cancer cells from blood. Biomedical Microdevices, 11, 4,
883-892, 2009.
13. HX Fu, Hu C, Chan GK,
Lim CT, Effects of magnesium salt concentrations on B-DNA overstretching
transition, European Physical Journal E, 29, 1, 45-49, 2009.
14. Hou HW, Li QS, Lee
GYH, Kumar AP, Ong CN, Lim CT, Deformability
study of breast cancer cells using microfluidics, Biomedical Microdevices, 11,
3, 557-564, 2009.
15. Yow SZ, Quek CH, Yim EKF, Lim CT, Leong
K, Collagen-based
fibrous scaffold for spatial organization of encapsulated and seeded human
mesenchymal stem cells, Biomaterials, 2009.
16. Sun L, Han RPS, Wang
J, Lim CT, Modeling the size-dependent elastic properties of polymeric
nanofibers, Nanotechnology, 2008.
17.
L
Varghese B, Zhang YS, Dai
L, Tan VBC, Lim CT, Sow CH, Structure-Mechanical Property of Cobalt Oxides
Nanowires with Different Chemical Compositions, Nano Letters, 2008.
18. Li QS, Lee GYH, Ong CN, Lim CT, AFM indentation study
of breast cancer cells, Biochemical and Biophysical Research Communications,
2008.
19.
Gohil
S, Hutchings CL, Fernandez KM, Kats L, Li A, Lim CT, Cooke BM, Rheological
modification of red blood cells by Babesia parasites, Biorheology, 45, 1-2: 41,
2008.
20.
Li
A, Lim TS, Shi H, Yin J, Tan KSW, Lim CT, Single molecular force spectroscopy
study of Plasmodium falciparum-infected erythrocyte cytoadherence to
endothelial receptors , American Journal of Tropical Medicine and Hygiene, 79,
6, 348, 2008.
21.
Shi
H, Li A, Yin J, Tan KWS, Lim CT, AFM study of the extracellular and the
cytoplasmic surfaces of Plasmodium falciparum infected erythrocyte membranes, American Journal of Tropical Medicine and Hygiene, 79, 6, 355-356,
2008.
22. Vedula SRK, Lim TS, Hunziker W, Lim CT, Mechanistic
Insights into Physiological Functions of Cell Adhesion Proteins Using Single
Molecule Force Spectroscopy, Molecular & Cellular Biomechanics, 2008.
23. im
TS, Vedula SRK, Shi H, Kausalya
PJ, Hunziker W, Lim CT, Probing
Effects of pH change on Dynamic Response of Claudin-2 Mediated Adhesion Using
Single Molecule Force Spectroscopy, Experimental Cell
Research, 2008.
24. Kishen A, Sum CP,
Matthew S, Lim CT, Influence of irrigation regimens on the adherence of
Enterococcus faecalis to root canal dentin, Journal of Endodontics, 2008.
25. Varghese B, Reddy MV,
Zhu Y, Chang SL, Teo CH, Subba Rao GV, Chowdari BVR, Wee ATS, Lim CT, Sow CH,
Fabrication of NiO nanowalls electrodes for high performance lithium ion
battery, Chemistry of Materials, 2008.
26.
Zhu
YW, Zhang YS, Cheong FC, Sow CH, Lim CT, Annealing effects on the elastic modulus
of tungsten oxide nanowires, Journal of Materials Research, 2008.
27.
Vedula
SRK, Lim TS, Kirchner E, Guglielmi KM, Dermody TS, Stehle T, Hunziker W, Lim
CT, A comparative molecular force spectroscopy study of homophilic JAM-A
interactions and JAM-A interactions with reovirus attachment protein sigma-1,
Journal of Molecular Recognition, 2008.
28. Vedula SRK, Lim TS, Kausalya PJ, Lane B, Rajagopal G, Hunziker W, Lim CT,
Quantifying
forces mediated by integral tight junction proteins in cell-cell adhesion, Experimental
Mechanics, 2008.
29. Reddy MV,
Yu T, Sow CH, Shen ZX,
30. Zhu YW, Moo AM, Yu T, Xu XJ, Gao XY, Liu YJ, Lim CT, Shen ZX, Ong CK, Wee
31. Zhang YZ, Venugopal JR, El-Turki A, Ramakrishna S, Lim
CT, Su B, Electrospun Biomimetic Nanocomposite Nanofibers of Hydroxyapatite/Chitosan
for Bone Tissue Engineering, Biomaterials, 29, 32, 4314-4322, 2008.
32. Lim TS, Vedula SRK,
Hunziker W, Lim CT, Kinetics of Adhesion Mediated by Extracellular Loops of
Claudin-2 as Revealed by Single Molecule Force Spectroscopy, Journal of Molecular
Biology, 381, 681-691, 2008.
33. Zhu, YW, Lim X, Sim
MC, Lim CT, Sow CH, Versatile transfer of aligned carbon nanotubes with PDMS as
the intermediate, Nanotechnology, 19, 325304, 2008.
34. Varghese B, Sow CH, Lim CT, Nb2O5 Nanowires as
Efficient Electron Field Emitters, Journal of Physical Chemistry C, 112,
27, 10008–10012, 2008.
35. Zhang YZ, Su B, Lim CT, Electrospinning Nanocomposite
Nanofibers of Hydroxyapatite/Chitosan, Advanced Materials Research, 47-50,
1363-1366, 2008.
36. Lim CT, Tan EPS, Ng SY, Effects of
Crystalline Morphology on the Tensile Properties of Electrospun Polymer
Nanofibers, Applied Physics Letters, 92,
141908, 2008.
37. Zheng, Z, Yan B, Zhang JX, You YM, Lim CT, Shen ZX, Yu T,
Potassium tungsten bronze nanowires: Polarized micro-Raman scattering of
Individual nanowires and electron field emission from nanowire films. Advanced
Materials, 20, 352-356, 2008.
38. Zhang YZ, Su B, Lim CT, Ramakrishna S, Chitosan Nanofibres from an
Easily Electrospinnable UHMWPEO Doped Chitosan Solution System,
Biomacromolecules, 9, 1, 136-141, 2008.
39. She XL, Song GJ, Peng Z, Li JJ, Lim CT, Tan EPS, Lv L, Zhao XS,
Nanocables prepared from polyamide 66 nanotubes enveloping pt nanowires by a
secondary-template method , Polymer Journal, 39, 10, 1025-1029, 2007.
40. Lim TS, Vedula SRK,
Kausalya J, Hunziker W, Lim CT, Single Molecular Level Study of Claudin-1
Mediated Adhesion, Langmuir, 24, 490-495, 2007.
41. Cheong FC,
Varghese B, Zhu YW, Tan
EPS, Dai L, Tan VBC, Lim CT, Sow CH, WO3-x
nanorods synthesized on a thermal hotplate. Journal of Physical Chemistry, 111,
46, 17193-17199, 2007.
42.
Varghese
B, Teo CH, Zhu YW, Reddy MV, Chowdari BVR, Wee ATS, Tan VBC, Lim CT, Sow CH, Co3O4
Nanostructures with different morphologies and their Field Emission Properties.
Advanced Functional Materials, 17, 12, 1932-1939, 2007.
43. Yu T, Varghese B,
Shen ZX, Lim CT, Sow CH, Large-scale metal oxide nanostructures on
template-patterned microbowls: A simple method for growth of hierarchical
structures. Materials Letters, 62, 3, 389-393, 2007.
44. Reddy MV, Yu T, Sow
CH, Shen ZX, Lim CT, Rao CVS, Chowdari BVR. Nano-flake α-Fe2O3 as an anode material for
Li-ion batteries, Advanced Functional Materials, 17, 15, 2792-2799, 2007.
45.
Unnikrishnan VU, Unnikrishnan GU, Reddy JN,
Lim CT. Atomistic-mesoscale coupled mechanical analysis of polymeric nanofibers. Journal of Materials Science, 42, 21, 8844-8852, 2007.
46. Hutchings CL, Li Ang,
Fernandez KM, Fletcher T, Jackson LA, Molloy JB, Jorgensen WK, Lim CT, Cooke
BM, New insights into the altered
adhesive and mechanical properties of red blood cells parasitised by Babesia
bovis. Molecular Microbiology, 65, 4, 1092-1105, 2007. (appear on
the cover of this issue)
47. Vedula SRK, Lim TS, Shi H, Kausalya JP, Lane B,
Rajagopal G, Hunziker W, Lim CT, Molecular force spectroscopy of homophilic
nectin-1 interactions. Biochemical and Biophysical Research Communications,
362, 4, 886-892, 2007.
48.
Mills
JP, Diez-Silva M, Quinn DJ, Dao M, Lang MJ, Tan KSW, Lim CT, Milon G,
David PH, Mercereau-Puijalon O, Bonnefoy S, Suresh S, Effect of
plasmodial RESA protein on deformability of human red blood cells
harboring Plasmodium falciparum,
Proc Natl Acad Sci, 104, 22, 9213–9217,
2007.
49. Chong KF, Loh KP, Vedula SRK, Lim CT,
Sternschulte H, Steinmüller D, Sheu FS, Zhong YL, Characterization of cell
adhesion properties of photochemically functionalized diamond surfaces,
Langmuir, 23, 5615-5621, 2007.
50. Chong EJ, Phan TT, Lim IJ, Zhang YZ, Bay BH, Ramakrishna S, Lim CT, Evaluation of electrospun
51. Tan EPS, Zhu Y, Yu
T, Dai L, Sow CH, Tan VBC, Lim CT. Crystallinity and surface effects on the Young’s
modulus of CuO nanowires. Applied Physics Letters, 90, 16, 163112-163115, 2007.
(also in Virtual Journal of Nanoscale Science & Technology, 15, 17, 2007.
52. Cheong FC, Varghese B, Sindhu S, Liu CM, Valiyaveettil S, Bettiol AA, Van Kan JA, Watt F, Chin WS,
53. Li X, Liu KL, Li J, Tan EPS, Chan LM, Lim CT, S H Goh.
Synthesis, Characterization, and
Morphology Studies of Biodegradable Amphiphilic Poly[(R)-3-hydroxybutyrate]-alt-Poly(ethylene
glycol) Multiblock Copolymers. Biomacromolecules,
7, 11,
3112-3119, 2006.
54. Li A, Lee PY, Ho B, Ding JL, Lim CT. Atomic force microscopy study of the antimicrobial action of
Sushi peptides on Gram negative bacteria.
55. Zhu YW, Teo CH, Xu XJ, Yu T, Lim CT, Ong CK, Thong JTL, Sow CH, Effects of O2 and Ar reactive ion etching on the
field emission properties of aligned CuO nanowire films.
56. Yu T, Sow CH, Xu XJ, Zhu YW, Lim CT, Thong JTL, Formation of α-Fe2O3 nanoflakes by
heating Fe in air.
57. Fu HX, Koh CG, Chen H, Lim CT, Experimental and numerical studies on B-
58. Cheong FC, Zhu YW,
Varghese B, Lim CT, Sow CH, Direct Synthesis of Tungsten Oxide Nanowires on
Microscope Cover Glass, Advances in
Science and Technology, 51, 1-6, 2006.
59. Varghese B, Fook CC, Sindhu S, Yu T, Lim CT, Valiyaveettil S, Sow CH. Size
Selective Assembly of Colloidal Particles on Template by Directed Self Assembly
Technique.
Langmuir, 22, 8248-8252, 2006.
60. Lim CT, Vedula SRK, Lim TS, Kausalya PJ, Gunaretnam
R, Hunziker W. Molecular interactions of tight junction proteins in cell-cell
interaction. Journal of Biomechanics, 39, Supplement 1 (2006): S241.
61. Li A, Mansoor AH, Tan KSW, Lim CT, Observations on the internal
and surface morphology of malaria-infected blood cells using optical and atomic
force microscopy, Journal of Microbiological Methods, 66, 3, 434-439,
2006.
62. Chew SY, Hufnagel TC,
63. Tan EPS,
64. Li PH, Qu YL, Xu XJ, Zhu YW, Yu T, Chin KC, Mi J,
Gao XY, Lim CT, Shen ZX, Wee
65. Tan EPS and Lim CT. Effects of
annealing on the structural and mechanical properties of electrospun polymeric
nanofibres. Nanotechnology, 17, 2649-2654, 2006.
66. Zhang
YZ, Wang Z, Feng Y, Li J,
67. Zhang YZ, Feng Y, Huang ZM, Ramakrishna A, Lim CT.
Fabrication of Porous Electrospun Nanofibers, Nanotechnology, 17, 901-908, 2006.
68. Yu T, Zhu YW, Xu XJ, Yeong KS, Shen ZX, Chen P, Lim
CT, Thong JTL, Sow CH. Simple nanoscience: Substrate-friendly synthesis of
metal oxide nanostructures using a hotplate. Small, 2, 1, 80-84, 2006.
69. Zhang YZ,
Venugopal J, Huang ZM, Lim CT, Ramakrishna S, Crosslinking of the electrospun gelatin nanofibers. Polymer, 47, 8, 2911-2917, 2006.
70. Song T, Zhang YZ, Zhou TJ,
71. Zhou EH, Lim CT, Quek ST,
Finite Element Simulation of the Micropipette Aspiration of a
Living Cell undergoing Large Viscoelastic Deformation,
Mechanics of Advanced Materials & Structures, 12, 6, 501-512, 2005.
72. Li J, Ni XP, Li X, Tan NK, Lim CT, Ramakrishna S, Leong KW, Micellization Phenomena of Biodegradable
Amphiphilic Triblock Copolymers Consisting of Poly(β-hydroxyalkanoic acid) and Poly(ethylene oxide). Langmuir, 21, 19, 8681-8685, 2005.
73. Tan EPS, Lim CT. Nanoindentation study of nanofibers. Applied Physics Letters, 87, 123106-123109, 2005.
74. Zhang Y Z, J R Venugopal, Z M Huang, C T Lim and S
Ramakrishna, Characterization of the surface biocompatibility of the
electrospun
75. Yu T, C H Sow, A Ganti Mahapatruni, F C Cheong, Y W Zhu, K C Chin,
X J Xu, C T Lim, Z X Shen, J T L Thong, A T S Wee, Patterning and fusion of CuO
nanorods with focused laser beam. Nanotechnology, 16, 8, 1238-1244, 2005.
76. Hairul Nizam BR,
77. Zhu Y W, T Yu, X J Xu, Y J Liu,
C T Lim, A T S Wee, J T L Thong, C H Sow. Efficient
field emission from alpha-Fe2O3 nanoflakes on an AFM tip. Applied Physics
Letters, 87,
023103-1-023103-3, 2005.
78. Yu,T, Zhu Y, Xu X, Shen Z, Chen P, Lim CT, Thong JTL, Sow CH,
Controlled growth and field emission properties of cobalt oxide nanowalls,
Advanced Materials, 17, 1595-1955, 2005.
79. Li J Dao M, Lim CT, Suresh S, Spectrin-level modeling of the cytoskeleton and optical tweezers
stretching of the erythrocyte, Biophysical
Journal, 88, 3707-3719, 2005.
80. Lim CT, Q Lan, EH Zhou, A Li, KSW Tan, JP Mills, M
Dao, S Suresh, Connections between biomechanical states and the onset and
progression of a malaria infected red blood cell. Biorheology, vol 40, no 12
(2005): 70.
81. Zhou, EH, CT Lim, KSW Tan, MH Ammar, CH Lim, ST
Quek, Quantitative evaluation of the capillary obstruction hypothesis in
malaria pathology. Biorheology, vol 40, no 12 (2005): 66.
82.
83. Jiang H, Liu XY,
84. Chng HK, Ramli HN,
Yap AUJ and
85. Tan EPS, Goh CN, Sow
CH and
86. Tan EPS, Ng SY, Lim CT. Nano tensile testing of a
single ultrafine polymeric nanofiber. Biomaterials,
26, 13, 1453-1456, 2005.
87. Zhu YW, Cheong FC, Yu T, Xu XJ, Lim CT, Thong JTL, Shen ZX, Ong
CK, Liu YJ, Wee
88. Zhu YW, Yu T, Cheong FC, Xu XJ, Lim CT, Tan VBC, Thong JTL, Sow
CH, Large-scale synthesis and field emission properties of vertically oriented
CuO nanowire films, Nanotechnology, 16, 88-92, 2005.
89. Zhang YZ, Ouyang HW, Lim CT, Ramakrishna S and Huang
ZM. Electrospinning of Gelatin fibers and Gelatin/
90. Nai MH,
91.
92. Mills JP, Qie L, Dao
M, Lim CT, Suresh S, Nonlinear Elastic
and Viscoelastic Deformation of the Human Red Blood Cell with Optical Tweezers. Mechanics and
Chemistry of Biosystems, 1, 3, 169-180, 2004.
93. Tan EPS,
94. Tan EPS,
95. Huang ZM, Zhang YZ, Ramakrishna S, Lim CT,
Electrospinning and mechanical characterization of gelatin nanofibers. Polymer, 45, 15, 5361-5368, 2004.
96. Zhang YZ,
Huang ZM, Xu XJ, Lim CT, Ramakrishna S, Preparation of Core-Shell Structured
97. Sow CH, Bettiol AA, Lee YYG, Cheong FC,
98. Yap AUJ, Chung SM, Chow WS, Tsai KT,
99. Chung SM, Yap AUJ, Koh WK, Tsai KT, Lim CT,
Measurement of Poisson ratio of dental composite restorative materials.
Biomaterials, 25, 13, 2455-2460, 2004.
100.
Dao M, Lim CT, Suresh S, Mechanics of the human red blood cell
deformed using optical tweezers. Journal of the Mechanics & Physics of
Solids, 51, 2259-2280, 2003.
101.
Yap AUJ, Lee MK, Chung SM, Tsai KT, Lim
CT. Effect of food-simulating liquids on shear punch strength of composite and
polyacid-modified restorative. Operative Dentistry 28, 5, 529-534, 2003.
some
NATIONAL/INTERNATIONAL MEDIA COVERAGE
1.
Knowledge
Enterprise, Mark of Excellence, Vol 9, No 3, Sep 2009.
2.
International Herald
Tribune, “Research is a national
priority”, 7 July 2009.
3.
The Straits Times, NUS
team bags prize for cancer cell catcher,
19 Jun 2009.
4. Newshub - NUS News Portal, Third Research Centre of Excellence at NUS, 20 February, 2009.
5. Knowledge Enterprise, Unravelling mysteries behind
the mechanics of diseases, February, Vol 8, No 7, 2009.
6. Pharma Focus Asia Magazine, Cover Story-R&D at the Nano Scale, July,
Iss 7, 2008.
7. Radio International interview, Sep, 2007.
8. Knowledge Enterprise, RESA, a culprit behind
malaria, Jul 2007.
9. Innovation magazine, Nanobiomechanics - An emerging
technology to study human diseases, Vol. 6, No. 3, 2006.
10. Lianhe Zaobao (National Chinese newspaper), National University of
Singapore Centennial Professorships,
11. The Alumnus, Operation Malaria, Issue no. 66, 16-17, Jul 2006.
12. Knowledge
13. The Straits Times: Pals use
nanotech to study malaria,
14. The New paper:
15. MIT Technology Review, 10 Emerging Technologies and
their impact: Nanobiomechanics, Mar/Apr 2006.
16.
Knowledge Enterprise,
17. Asia Pacific Biotech (Special Issue - Bioengineering in Asia-Pacific), "Single cell mechanics & its connection to human diseases", vol. 9, No. 14, July 2005.
18. Knowledge Enterprise, Stretching diseased red blood cells leads to outstanding paper award, Apr 2005.
19. Materials Today, "Nanotools study disease in single cells", pg. 15, February 2005.
20. MIT Tech Talk news, "Team engineers cell-deforming technique to help understand malaria", vol 49, issue 13, 15 Dec 2004.
21. The Straits Times: 50 Young Singaporeans to Watch, 6 Nov 2004.
22. Lianhe Zaobao (National chinese newspaper), 8 Oct 2004.
23. Channel U Chinese News, 7 Oct 2004.
24. Radio interview by Norwegian Broadcasting Corporation under "Current Affairs", Channel 2, 2004.
25. New Frontiers, Documentary, Apr 2004.
26. Innovation Magazine: Optical Tweezers Provide New Insights into Malaria-Infected Red Blood Cells, 4, 3, pp.40, Sep 2003.
27. The Straits Times, Science & Tech Section: NUS staff bid to crack malaria mystery, 14 Aug 2003.
28. The New Scientist, World's No.1 Science & Technology News Section, 17 Jul 02.
29. The Straits Times, Science & Tech Section: Bone collector working to end aches and pains, 10 Jun 2002.
30. The Straits Times, Prime News Section: NUS Dons research unbreakable cell phones, 15 Jul 2002.
31. Asia.internet.com, Nanotech News Section: Unleashing the Bionanotechnology Talent, 11 Jun 2002.