NanoGuide - Intraluminal guidance nanofibrous yarn

NanoGuide is a novel intra-luminal guidance channel which can be used with commercially available nerve conduit. It is made of 100% biodegradable PLGA.

Currently, there are no commercially available nerve conduits with intra-luminal guidance channel.

NanoGuide
    Advantages

  • Aligned nanofibers act as guidance channel for faster axon extension
  • Presence of nanofibrous yarn reduces incidence of tube collapsing in-vivo
  • Can be used with commercial nerve tubes
  • Biodegradable material which will be resorbed by the body
  • Possibility to incorporate proteins and peptides into nanofibers
  • No donor site morbidity
  • Broad range of nerve guide size
NanoGraft - Biomineralized scaffold for bone repair

The Nanograft is made out of biodegradable nanofibers and hydroxyapatite nanoparticles. It is designed to be remodeled and replaced by native bone during the healing process.

NanoGraft
    Advantages

  • Osteoblasts have been shown in in-vitro studies to adhere and proliferate well on mineralized nanofibrous assembly.
  • Biodegradable material which will be resorbed by the body
  • Biomineralized scaffold – Hydroxyapatite has low crystallinity similar to natural hydroxyapaptite.
    -Facilitates induction of new bone
    -Easier resorption
  • Possibility of including heparin sulfate or bone morphogenic proteins (BMP) into nanograft.
NanoStent - Nanofibers covered stent (NCS)

Using a novel nanofibrous coating process, aligned nanofibers are uniformly coated longitudinally on the surface of pre-deployed bare metal stent.

NanoStent
    Advantages

  • Nanofibrous sheath acts as barrier to restenosis
  • Minimum resistance during stent deployment
  • Longitudinally aligned nanofibers reduces friction between stent wall and blood vessel
  • Biodegradable material which will be resorbed by the body
  • In-vitro studies have shown excellent endothelization of nanofibrous surface
  • Possibility to incorporate drugs into nanofibers
Nanofiber yarn production Continuous Nanofibrous yarn

Ligament and tendon replacement graft, smart fabric, sutures. These are just some of the possible applications of our nanofibrous yarn. A single micro-yarn is made out of tens of nanofibers aligned in the same direction. Our process is able to spin continuous yarn up to a speed more than 80 m/min. Yarn made out of biodegradable polymers, natural polymers and industrial polymers have been fabricated.

Details

PATENTS/INVENTION DISCLOSURES: 

  1. Liu Ying Jun, Dong Yi  Xiang, Abhishek Kumar, Seeram Ramakrishna. A coating and a method of coating. International patent Application number PCT/SG2008/000476 filed on 11 December 2008.
  2. Liu Ying Jun, Ramakrishnan Ramaseshan, Dong Yi Xiang, Abhishek Kumar, Seeram Ramakrishna. A portable electrospinning apparatus. International patent Application number PCT/SG2008/000444 filed on 20 November 2008.
  3. Hui Shan Koh, Wee Eong Teo, Kwan-Ho Chan, Seeram Ramakrishna, Ter Chyan Tan, Mark Edward. Biomimetic Fibrous Implant Devices for Nerve Repair. US Provisional Patent Application No. 61/084,306. 29 July 2008.
  4. Kwan-Ho Chan, James W Larrick, Michael Raghunath, Seeram Ramakrishna, Susan Liao, Kun Ma. Method and Construction of a Cell Composite for Tissue Repair. US Provisional Patent Application No. 61/133,298. 27 June 2008.
  5. Kwan-Ho Chan, Yixiang Dong, Wee Eong Teo, Seeram Ramakrishna. Covered stent coated with aligned or random nanofiber by electrospinning. US Provisional Patent Application Number: 60/984,803. 12 December 2007.
  6. J. Venugopal and S. Ramakrishna. A Process for the Novel Modified Biocompatible Polymer Nanofibrous Scaffolds for Tissue Engineering. Filing in preparation.
  7. S. Liao, S. Ramakrishna, and C. Chan, Deposition of Nano-hydroxyapatite on Nano-textured Scaffold. Invention Disclosure Submitted to INTRO on 08 December 2006.
  8. H-Q Mao, K.W. Leong, K.N. Chua and S. Ramakrishna. Functional Fibers for Ex Vivo Expansion of Stem and Progenitor Cells. Report of Invention submitted to Johns Hopkins Technology Transfer (JHTT). Reference no: 5093, 8 November 2006.
  9. W.E. Teo, K. Fujihara, C. Chan and S. Ramakrishna. Three-Dimensional Scaffold Constructed from Electrospun Nanofiber Yarns. Provisional US Patent Application No. 60/845,318, 18 September 2006.
  10. S. Sundarrajan and S. Ramakrishna. Nanocomposites Based on Electrospun Nanofibers for Protection Against Chemical and Biological Warfare Agents. Invention Disclosure filed in Singapore, 4 0 20032507, 22 March 2006. Provisional US Patent Application No. 60/922,995, 11 April 2007.
  11. F. Yang, R. Inai, T. Yong and S. Ramakrishna. Three-Dimensional Submicron Fibrous Scaffolds with Controlled Fiber Orientation for Tissue Engineered Vascular Graft and Method Thereof. US Provisional Patent Application No. 60/760,367, 20 January 2006.
  12. K. Fujihara, M. Kotaki, C. Chan and S. Ramakrishna. Nanofiber Construct and Method of Preparing Thereof.  Singapore Patent Application No. 200508100-5, 15 December 2005, and US Patent Application No. 11/300,379, filed 15 December 2005, and Publication No. US 2006/0154063 A1, Published 13 July 2006.
  13. E. J Chong, C.T. Lim, S. Ramakrishna, T.T. Phang and J.I. Lim. A Composite, Method of Producing the Composite and Uses of the Same. Provisional US Patent Application No. 60/614,431, 29 September 2004 and International PCT Application No. PCT/SG2005/000323, 29 September 2005, Publication No. WO 2006/036130 A1, 06 April 2006. Japanese Patent Application No. 2007-534548, 26 July 2007. Singapore Patent Number 130912 [WO2006/036130], June 2008.
  14. R. Gopal, K. Fujihara, V.K. Ganesh, K.W.C. Foong, S. Ramakrishna and C.L. Chew. Fiber-reinforced Composite and Methods of Forming the Same. European Patent Application No. 03783037.9-2307-SG0300291, 31 January 2006, and US Patent Application No. 10/743,562, 24 March 2005, and Singapore Patent Application No. 200504159-5, 24 December 2003.
  15. Wee Eong Teo, Kazutoshi Fujihara, Casey Kwan-Ho Chan, Seeram Ramakrishna. Fiber Structures and Process for their preparation. WO 2008/036051. 27 March 2008.
  16. K. Fujihara, M. Kotaki, S. Ramakrishna and C. Chan. Hybrid Composite Nanofiber Scaffolds and Method Thereof. US Provisional Patent Application No. 60/636,356, 15 December 2004.
  17. E.J Chong, C.T. Lim, S. Ramakrishna, T.T. Phang and J.I. Lim. Nanofibrous Mat for Tissue Engineering, Wound Dressing and Dermal Reconstitution. Provisional US Patent Application No. 60/614,431, 29 September 2004.
  18. Teo W.E., M. Kotaki and S. Ramakrishna. An Apparatus and Method for Producing Nanofibres. Singapore Patent Application No. 200404159-6, 29 July 2004.
  19. C.T. Lim, S.S. Chia and S. Ramakrishna. Apparatus for Electrostatic Deposition of Materials. Singapore Patent Application No. 200403355-1, 4 June 2004.
  20. R. Murugan and S. Ramakrishna. Production of Nano-sized Hydroxyapatite Particles. Singapore Patent Application No. 200401898-2, 6 April 2004, and Provisional US Patent Application No. 10/819,858, 7 April 2004, Publication No. US-2005-0226939-A1, published on 13 October 2005 (http://www.freshpatents.com/Production-of-nano-sized-hydroxyapatite-particles-dt20051013ptan20050226939.php).
  21. Teo W.E., M. Kotaki, and S. Ramakrishna. Process and Apparatus for Manufacturing Aligned Nanofiber Tubes and Other Structures. Provisional US Patent Application No. 60/492,702, 5 August 2003.
  22. K. Teo, K. Fujihara, P. L. Loh, K.W.C. Foong, V.K., Ganesh, S. Ramakrishna, and C. L. Chew. Fiber Reinforced Composite And Method of Forming the Same. US Patent Application Publication No. 2005/0008984, 13 January 2005 and PCT Patent Application No PCT/SG2004/00185, 18 June 2004.
  23. S.S. Chia, C.T. Lim, Y.Z. Zhang and S. Ramakrishna. Highly Productive Electrospinning Apparatus with Multiple Spinneret System. Provisional US Patent Application No. 60/475,921, 5 June 2003.
  24. Shu Wang, S. Ramakrishna and Bini T.B. Medical Guide Tubes. Provisional US Patent Application No. 10/328,930, December 2002, and US Patent No 7,135,040 B2, 14 Nov 2006.
  25. S. Ramakrishna, V. K. Ganesh, S. H. Teoh, P.L. Loh and C.L. Chew. Fiber Reinforced Composite Product with Graded Stiffness. Singapore Patent No. 79227, 27 February 2004, and US Patent No 6,287,122 B1, 11 September 2001.
  26. S. H. Teoh, Z.G. Tang and S. Ramakrishna.  Transparent Composite Membrane.  Singapore Patent Application No. 97026730-6, 1997, and US Patent No 6,652,966 B1, 25 Nov 2003.


 


Contact Information

Mr TEO Wee Eong
Project Manager
Healthcare and Energy Materials Laboratories, NUSNNI (Faculty of Engineering)
National University of Singapore
Blk E3 #05-12 2 Engineering Drive 3 Singapore 117576

Tel: 65-65164272
Fax: 65-67730339
Email: engtwe@nus.edu.sg

 

 

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