µ-TE lab

Micro-scale tissue models for human diseases and toxicology

Graduate Students

Geetika Sahni

Geetika Sahni has completed her B.Eng in Biotechnology and M.Tech in Nanotechnology from Indian Institute of Technology (IIT) Roorkee, India. She enrolled as a PhD student in Department of Biomedical engineering, NUS in 2014 and joined this Micro-tissue engineering lab under the supervision of Dr. Toh Yi-Chin. Geetika’s research work is focused on developing human pluripotent stem cell based 3D neuroectoderm model to study neuronal diseases. She aims to integrate stem cell micropatterning techniques to design human based platforms for model the effects of drug and genetically-induced neuropathogenesis in vitro. Her previous research was focused on Nanobiotechnology – Novel methods for synthesis of hydroxyapatite based nanocomposite for biomedical applications. She also has a research experience in clinical proteomics and molecular genomics.

Seep

Seep joined NUS as a PhD student in Aug 2014. She finished her Master from Indian Institute of Technology Bombay, India in Biomedical Engineering and her undergraduate is in Biotechnology. Her previous interest has been into various research fields which included Bionanotechnology during her master studies and Molecular Biology during the undergraduate studies. Her masters’ thesis included designing of antibacterial drug loaded nanoparticle and testing its activity on bacteria. Her undergraduate dissertation was regarding gene cloning in bacteria.
She is currently working on testing the effects of shear stress and substrate topography on endothelial cell behaviour relevant to vascular tissue engineering.

Chong Lor Huai

Chong Lor Huai is a PhD student at Department of Biomedical Engineering, National University of Singapore (NUS) under supervision of Dr Toh Yi-Chin. She received her B.Eng with honours in Biomedical Engineering from Universiti Teknologi Malaysia (UTM), Malaysia in year 2014. Upon completing her undergraduate study, she worked as a research assistant on Polycarprolactone (PCL) and Gelatin (GE)-based electrospun nanofibers for tissue engineering and drug delivery application, at the Faculty of Biosciences and Medical Engineering (FBME), UTM before joining NUS in August 2015.
Currently, her research interest is to develop a liver-skin chip to model systemic interactions between the liver and skin during drug testing specifically for drugs with dermal indications. She is interested in developing 3D microfluidic cell-based models to mimic the systemic interactions in Micro-tissue engineering lab.

 Lucas Ong

Lucas is currently pursuing his M.Eng in the department of biomedical engineering in NUS under the mentorship of Dr. Toh Yi-Chin. He graduated and received his B.Eng (Biomedical Engineering) from the National University of Singapore (NUS) and was also part of the varsity swim team.
His research project is a collaborative project with GIS and MIT on utilizing microfluidics to study the cell pairing of cancer cells. He is currently utilizing a cell pairing device developed by Joel Voldman’s group from MIT to fuse metastatic and non-metastatic cancer cells, culture them and analyze them using PCR, imaging and gene sequencing.
Lucas’s previous research involvements included studying the effects of biowastes secreted by mechanically damaged C2C12 mouse myoblasts on cell toxicity and compressive damage threshold in the Chinese University of Hong Kong, and on the development of silk microspheres that can be manipulated by a magnetic field for location specific drug delivery.

Qu Yinghua

Yinghua obtained her bachelor’s degree in Pharmacy in Fudan University and M.Eng in Biomedical Engineering in Southeast University in China. Prior to PhD studying, she worked as toxicology support manager in InvitroCue (IVQ), which is an A*STAR spin off company. She managed projects, such as NASH study with collaboration of Thermo Fisher, and also involved in projects related to establishing 3D hepatocytes in vitro culture model for drug testing assay and stem cell hepatic differentiation during working in IVQ and Institute of Bioengineering and Nanotechnology (IBN). Yinghua’s current research interest is to work on using gene editing tools and engineered in vitro human neural model to study developmental neuropathogenesis.

Irsyad Ramthan

Irsyad is currently pursuing his M.Eng in the Department of Biomedical Engineering in NUS under the mentorship of Dr. Toh Yi-Chin. He received his B.Eng (Biomedical Engineering) from the National University of Singapore (NUS).
Irsyad’s current work in the Micro-Tissue Engineering revolves around the development of a microfluidic personalised cancer drug testing platform which would potentially enable the use of primary tumour cells. Previously, he did his final year project at Robert Bosch (SEA) Research and Technology Centre, where he investigated and developed novel ion sensors for healthcare applications, and subsequently did an independent study in the Micro-Tissue Engineering lab, where he investigated osteogenic differentiation potential of neural crest stem cells cultured in spheroids.
Irsyad is deeply interested in pushing biomedical engineering to the point where vital medical and diagnostic technologies are democratized in a similar manner in which the open source movement has democratized information technology. He is also an avid student and teacher of negotiation and conflict management, where he actively seeks opportunities to teach others not just to push for compromise, but to create value via active communication and creative problem solving.

Jean Fatien

Jean is currently pursuing his Master’s degree in Biomedical Engineering at NUS under the supervision of Dr. Toh Yi-Chin. His project focuses on the understanding of the development of the adipose tissue. He is working on stem cells from the umbilical cord of children born to healthy mothers and to GDM (gestational diabetes mellitus) mothers. Building on the PhD work of Dr. Anna G. Goralczyk he is differentiating MSCs into white and brown adipocytes in order to compare the phenotypical characteristics between cells from healthy and GDM affected children.
Jean’s previous work includes research in neurosciences: in the Behnia lab (Columbia University, NY, USA) he worked on color discrimination in the Drosophila brain. Jean also worked on digital PCR at Stilla Tehchnologies (Villejuif, France).
Jean’s M.Eng at NUS will conclude his Cycle Ingénieur Polytechnicien at Ecole polytechnique (Palaiseau, France), cycle during which he obtained his B.Eng.

Ching Tsz Him Terry

Terry received his B.Eng (Engineering Product Development) from Singapore University of Technology and Design (SUTD). He is currently a PhD student in the SUTD-NUS jointed degree program under the supervision of Michinao Hashimoto (SUTD) and Toh Yi-Chin (NUS). His interest involves applying engineering principle to biomedical applications. During his undergraduate days, he was involved in several healthcare developments in collaboration with Changi General Hospital. He co-invented Fuga (Patent Pending), a Pleural Drainage Device that aims to automate the current, time-consuming drainage procedure. He was also involved in the development of Bward (Patent Pending), a Real-time Blood Sensing and Wound Monitoring Device that continuously monitors wound-site after the removal of a central venous catheter. Terry’s current research interest is in 3D-printed devices for organs-on-a-chip.
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