µ-TE lab

Micro-scale tissue models for human diseases and toxicology

Graduate Students

Geetika Sahni

Geetika Sahni has completed her B.Eng in Biotechnology from University of Rajasthan, India and graduated with M.Tech in Nanotechnology from Indian Institute of Technology (IIT) Roorkee, India. She enrolled as a PhD student in Department of Biomedical engineering, NUS in 2014 and joined this Micro-tissue engineering lab under the supervision of Dr. Toh Yi-Chin.
Geetika’s research interest is focused on developing an organ-on-a-chip for neural system to explore its application to study the disease pathogenesis and drug testing. She aims to integrate nanotechnology aspects to device fabrication to control and enhance the invitro tissue formation on the chip.
Her previous research was focused on Nanobiotechnology – Novel methods for synthesis of hydroxyapatite based nanocomposite for various biomedical applications. She also has a research experience in clinical proteomics – Proteomic analysis of Crohn’s disease intestinal tissue for the identification of potential biomarkers and has worked in the domain of molecular genomics-Recombinant expression and purification of PvTRAg protein of Malaria parasite in Bacterial system.

Seep

Seep joined NUS as a PhD student in Aug 2014. She finished her Master from Indian Institute of Technology Bombay, India in Biomedical Engineering and her undergraduate is in Biotechnology. Her previous interest has been into various research fields which included Bionanotechnology during her master studies and Molecular Biology during the undergraduate studies. Her masters’ thesis included designing of antibacterial drug loaded nanoparticle and testing its activity on bacteria. Her undergraduate dissertation was regarding gene cloning in bacteria.
She is currently working on testing the effects of shear stress and substrate topography on endothelial cell behaviour relevant to vascular tissue engineering.

Chong Lor Huai

Chong Lor Huai is a PhD student at Department of Biomedical Engineering, National University of Singapore (NUS) under supervision of Dr Toh Yi-Chin. She received her B.Eng with honours in Biomedical Engineering from Universiti Teknologi Malaysia (UTM), Malaysia in year 2014. Upon completing her undergraduate study, she worked as a research assistant on Polycarprolactone (PCL) and Gelatin (GE)-based electrospun nanofibers for tissue engineering and drug delivery application, at the Faculty of Biosciences and Medical Engineering (FBME), UTM before joining NUS in August 2015.
Currently, her research interest is to develop a liver-skin chip to model systemic interactions between the liver and skin during drug testing specifically for drugs with dermal indications. She is interested in developing 3D microfluidic cell-based models to mimic the systemic interactions in Micro-tissue engineering lab.

 Lucas Ong

Lucas is currently pursuing his M.Eng in the department of biomedical engineering in NUS under the mentorship of Dr. Toh Yi-Chin. He graduated and received his B.Eng (Biomedical Engineering) from the National University of Singapore (NUS) and was also part of the varsity swim team.
His research project is a collaborative project with GIS and MIT on utilizing microfluidics to study the cell pairing of cancer cells. He is currently utilizing a cell pairing device developed by Joel Voldman’s group from MIT to fuse metastatic and non-metastatic cancer cells, culture them and analyze them using PCR, imaging and gene sequencing.
Lucas’s previous research involvements included studying the effects of biowastes secreted by mechanically damaged C2C12 mouse myoblasts on cell toxicity and compressive damage threshold in the Chinese University of Hong Kong, and on the development of silk microspheres that can be manipulated by a magnetic field for location specific drug delivery.

Qu Yinghua

Yinghua obtained her bachelor’s degree in Pharmacy in Fudan University and M.Eng in Biomedical Engineering in Southeast University in China. Prior to PhD studying, she worked as toxicology support manager in InvitroCue (IVQ), which is an A*STAR spin off company. She managed projects, such as NASH study with collaboration of Thermo Fisher, and also involved in projects related to establishing 3D hepatocytes in vitro culture model for drug testing assay and stem cell hepatic differentiation during working in IVQ and Institute of Bioengineering and Nanotechnology (IBN). Yinghua’s current research interest is to work on using gene editing tools and engineered in vitro human neural model to study developmental neuropathogenesis.
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