Cellular and Molecular Bioengineering Lab
Block E3A, #07-06
7 Engineering Drive 1
Phone: (65) 6516-5050
Multi-functional Nanocomposites for Biological Labeling
There have been tremendous advances in the development of in-situ
labeling and screening of different biological entities, ranging from
cells to DNAs. Many approaches have been developed for this purpose,
such as chemical encoding with molecular tags, organic fluorophores,
fluorescent colloids, and Raman fingerprints.
The development of
labeling materials has been critically important. Some materials such
as quantum nanodots, organic dyes and metal nanoparticles have
been extensively used for biological labeling, however, they have to
be surface modified to better suit their integration with biological
systems. Recently, synthesis of monodisperse polymer nanospheres has
stimulated great interest and incorporation of fluorophores in these
nanospheres is particularly attractive.
In these nanocomposites, organic
polymer can not only stabilize the nanoparticles in a solid matrix, but
also effectively combine the peculiar features of organic and inorganic
components and thus resulting in novel properties. These materials can
bring new and unique capabilities to a variety of biomedical
applications ranging from diagnosis of diseases to novel therapies.
Dr Zhang Yong
Micropatterning of Biomolecules via Manipulation of
Micropatterning of biomolecules, the attachment of biomoloecules
within designated regions on solid surfaces while preventing nonspecific
adhesion at other regions, forms the basis of microarray
technnology. It has found many applications in various fields such as
the diagnosis of disease, drug discovery, environmental testing,
biological studies, etc.
We are developing a new technique of
micropatterning which allows the integration of non-planar spots on
a planar microarray via anipulation of micro/nano spheres.